Is antenatal RhIg completely safe?

he administration of antenatal and postnatal Rh mmunoglobulin prophylaxis significantly prevents Rh D lloimmunization during pregnancy. A dose of 20 g anti-D gG protects against 1 mL of D-positive red blood cells or 2 mL f whole blood. Rh D-negative women if unsensitized receive ntenatal anti-D prophylaxis of 300 g at 28 weeks of pregancy and postnatal prophylaxis if the baby is Rh D positive. nitial trials concluded that postpartum immunoprophylaxis ecreased the incidence of Rh D immunization from 12–13% o 1–2% which was further shown to be reduced to 0.1% hanks to antenatal prophylaxis.1 Rh immunoglobulin (RhIg) dministration is quite safe during pregnancy although RhIg an cross the placenta and cause hemolysis of the red cells f D-positive fetuses. Unfortunately data is sparse on this erious adverse event. Herein we present an unusual case f hemolytic disease of newborn (HDN) with positive Direct oombs’ Test (DCT) due to antenatal RhIg prophylaxis in an h-negative mother.